2015-09-13 COLTS AT BILLS

FINAL SCORE: 14 - 27

2015-09-20 PATRIOTS AT BILLS

FINAL SCORE: 40 - 32

2015-09-27 BILLS AT DOLPHINS

FINAL SCORE: 41 - 14

2015-10-04 GIANTS AT BILLS

FINAL SCORE: 24 - 10

2015-10-11 BILLS AT TITANS

FINAL SCORE: 14 - 13

2015-10-18 BENGALS AT BILLS

FINAL SCORE: 34 - 21

2015-10-25 BILLS AT JAGUARS

FINAL SCORE: 31 - 34

2015-11-08 DOLPHINS AT BILLS

FINAL SCORE: 17 - 33

2015-11-13 BILLS AT JETS

FINAL SCORE: 22 - 17

2015-11-24 BILLS AT PATRIOTS

FINAL SCORE: 13 - 20

2015-11-29 BILLS AT CHIEFS

FINAL SCORE: 22 - 30

2015-12-06 TEXANS AT BILLS

FINAL SCORE: 21 - 30

2015-12-13 BILLS AT EAGLES

FINAL SCORE: 20 - 23

2015-12-20 BILLS AT WASHINGTON

FINAL SCORE: 25 - 35

2015-12-27 COWBOYS AT BILLS

FINAL SCORE: 6 - 16

2016-01-03 JETS AT BILLS

FINAL SCORE: 17 - 22